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α-Conotoxin MI
CAS No. 88217-10-1
α-Conotoxin MI ( ——— )
产品货号. M41036 CAS No. 88217-10-1
α-Conotoxin M I 是 mAChR 和 α1β1γδ nAChR 的选择性和有效的抑制剂，但对尼古丁刺激的多巴胺释放无影响。α-Conotoxin 毒素是一种小的、富含二硫的多肽，竞争性地抑制肌肉和神经元的尼古丁 AChR。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | 获取报价 | 有现货 |
|
| 50MG | 获取报价 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
生物学信息
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产品名称α-Conotoxin MI
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述α-Conotoxin M I 是 mAChR 和 α1β1γδ nAChR 的选择性和有效的抑制剂，但对尼古丁刺激的多巴胺释放无影响。α-Conotoxin 毒素是一种小的、富含二硫的多肽，竞争性地抑制肌肉和神经元的尼古丁 AChR。
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产品描述α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs.
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体外实验———
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体内实验α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits.
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同义词———
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通路Others
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靶点Other Targets
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受体mAChR; α1β1γδ nAChR
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研究领域———
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适应症———
化学信息
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CAS Number88217-10-1
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分子量1497.74
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分子式C58H92N22O17S4
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纯度>98% (HPLC)
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溶解度———
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SMILES———
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化学全称———
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kulak JM, et al. Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J Neurosci. 1997 Jul 15;17(14):5263-70. ?
产品手册
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